【摘要】 目的研究瞬态诱发耳声发射（ｔｒａｎｓｉｅｎｔｅｖｏｋｅｄｏｔｏａｃｏｕｓｔｉｃｅｍｉｓｉｏｎｓ，ＴＥＯＡＥ）和畸变产物耳声发射（ｄｉｓｔｏｒｔｉｏｎｐｒｏｄｕｃｔｏｔｏａｃｏｕｓｔｉｃｅｍｉｓｉｏｎｓ，ＤＰＯＡＥ）应用于新生儿听力筛选的可行性，探讨听力筛选的标准。方法应用Ｃｅｌｅｓｔａ５０３型耳声发射分析仪对１０８名新生儿（２１６耳）进行ＴＥＯＡＥ和ＤＰＯＡＥ听力筛选，与听性脑干反应（ａｕｄｉｔｏｒｙｂｒａｉｎｓｔｅｍｒｅｓｐｏｎｓｅ，ＡＢＲ）测试结果进行对照。结果当ＴＥＯＡＥ以波形总相关系数ｒ≥０．６０，ＤＰＯＡＥ以８个测试频率（０．７５～８ｋＨｚ）中５个以上测试频率的反应幅值超出正常第５百分位数（Ｐ５）为新生儿通过听力筛选的标准时，两者与ＡＢＲ测试结果对照，其共同阳性率（ｃｏｐｏｓｉｔｉｖｉｔｙ）均为１００％，共同阴性率（ｃｏｎｅｇａｔｉｖｉｔｙ）分别为９３．８％和９４．３％，且ＴＥＯＡＥ和ＤＰＯＡＥ筛选结果的相关性最佳，ｒ＝０．６５８３（ｎ＝２１６，Ｐ＝０．０００１）。结论耳声发射是一种快速而行之有效的新生儿听力筛选方法。应用ＴＥＯＡＥ和ＤＰＯＡＥ进行新生儿普遍性听力筛选时，ｒ≥０．６０和Ｐ５分别?更多还原

【Abstract】 Objective To evaluate the validity of transient evoked otoacoustic emissions (TEOAE) and distortion product otoacoustic emissions (DPOAE) in newborn hearing screening and to establish the feasible pass/fail criteria of screening. Methods One hundred and eight newborns (216 ears) were screened by TEOAE and DPOAE with Celesta 503 Cochlear Emission Analyzer. The outcome of OAE screening was compared with that of auditory brainstem response(ABR) test. Results When the criterion of passing TEOAE screening was based on the correlation coefficient of waveforms equal to or greater than 0.60 ( r ≥0.60),the co positivity and co negativity to the ABR results were 100 % and 93.8 % respectively. When the pass criterion of DPOAE was set as that the response levels were greater than the 5th percentile ( P 5) of the normal newborns in more than five out of eight frequencies, the co positivity and co negativity were 100 % and 94.3 % respectively. The outcome of TEOAE and DPOAE screening between r ≥0.60 and P 5 showed the best correlation, r = 0.658 3 ( n = 216, P = 0.000 1). Conclusion r ≥0.60 and P 5 were the feasible pass criteria of TEOAE and DPOAE for newborn hearing screening respectively. OAE proved to be an objective tool for rapid and effective test in universal newborn hearing screening.更多还原