【摘要】 观察低剂量辐射诱导儿童淋巴细胞大剂量辐射后DNA合成适应性反应。儿童淋巴细胞经过0.5,1.0,1.5,2.0,3.0,4.0cGy低剂量辐射后均可诱导适应性反应,以1.5 cGy最为明显,DRP为53.4％。经1.5 cGy辐射后6,24,48,72 h均存在适应性反应,以24h适应性反应表达最为明显,DRP为53.4％。1.5cGy辐射后1,3,5,7 Gy辐射亦存在适应性反应,以3 Gy表达最为明显。儿童淋巴细胞在0.5～4.0 cGy辐射后均能诱导大剂量辐射后DNA合成的适应性反应,以1.5cGy辐射后24h 3cGy辐射的适应性反应最为明显。更多还原

【Abstract】 To study the adaptive response of DNA synthesis induced by low doses radiation in children’s lymphocytes, lymphocytes of children were cultured for 24 h and divided into three groups. In the first group, culture of lymphocytes was irradiated by 0.5, 1.0, 1.5, 2.0, 3.0, 4.0 cGy after 24 h, it was exposed to 3 Gy. In the second group, it was exposed to 3 Gy after 6, 24, 48, 72 h culture of lymphocytes induced by 1.5 cGy. In the third group, it was exposed by 1, 3, 5, 7 Gy after 24 h culture of lymphocytes induced by 1.5 cGy. Then incorporation and measure were done as above. DRP was used to express the adaptive response. The adaptive response was induced respectively by 0.5, 1.0, 1.5, 2.0, 3.0, 4.0 cGy. DRP was 53.4% by 1.5 cGy. The adaptive response induced by 1.5 cGy could be observed after 6, 24, 48, 72 h and 1, 3, 5, 7 Gy radiation respectively. It was the most obvious in 24 h and 3 Gy radiation. The adaptive response of DNA synthesis can be induced by 0.5-4.0 cGy. When it is induced by 1.5 cGy for 24 h and exposed to 3 Gy, the DRP is the most obvious.更多还原