【摘要】 目的 :了解黄芪毛状根的药理作用。方法 :口服给药 ,观察黄芪毛状根对D 半乳糖所致衰老小鼠记忆力的影响及抗氧化作用 ;制备大鼠肾缺血再灌注模型 ,测定黄芪毛状根对肾组织超氧化物歧化酶 (SOD)活性及丙二醛 (MDA)含量的影响 ;测定环磷酰胺所致免疫功能低下小鼠口服黄芪毛状根后NK细胞活性。结果 :黄芪毛状根能改善衰老小鼠记忆力 ,提高脑、肝组织SOD活性 ,降低肝脏MDA含量 ;能降低缺血再灌注大鼠肾MDA含量及血肌酐浓度 ;能提高免疫功能低下小鼠NK细胞活性。结论 :与天然黄芪相似 ,黄芪毛状根具有抗衰老、抗过氧化及免疫调节作用。更多还原

【Abstract】 Objective:ToinvestigatetheeffectofhairyrootofAstragalusmembranaceus(HRA) .Method :HRAwere given 1 0 g/kgperdayfor 5 0daystoagedmicetreatedwithD galactose,andtheeffectonmemoryandantioxidantfunc tionswereestimated .AfteradministrationofHRA 1 0 g/kgforfourdays,anischemia reperfusionkidneymodelofratwas prepared .Thekidneyfunction ,activityofsuperoxidedismutase (SOD)andcontentofmalondialdehyde(MDA)inkidney wereexamined .MicewithimmunosuppressioninducedbycyclophosphamideweregivenorallyHRA 1 0 g/kgfor 1 2days. Theactivityofnaturalkiller (NK)cellswasmeasured .Result:HRAimprovedthememory ,raisedSODactivityinbrain andliver ,decreasedtheMDAcontentintheliverofagedmice,reducedtheMDAcontentinischemia reperfusionkidney , dcreasedthecreatininelevelinbloodofrats,andpromotedtheactivityofNKcellsinimmunosuppressedmice.Conclusion : SimilartothenaturalA .membranaceus,HRAhassenility preventing,antioxidizingandimmunomodulatingfunctions.更多还原