【摘要】 目的：观察博宁对肺癌骨转移的止痛效果。方法：应用博宁治疗及放射治疗对照研究。结果：４０例博宁治疗组患者骨痛的止痛总有效率为８７５％，显效率达５００％。其中，单用博宁组有效率为８４６％，博宁合并放疗组有效率为９１６％，博宁合并化疗组有效率为８６７％，三组间止痛效果无显著性差异（Ｐ＞００５）。４０例单纯放射治疗的骨转移患者止痛总有效率为８２５％，显效率为３５０％。博宁应用中除少数患者出现胃肠道反应外，无明显其他毒副反应发生。结论：博宁是一种安全、有效的新一代双膦酸盐制剂，可与放疗、化疗联合应用于肺癌骨转移患者的治疗中。更多还原

【Abstract】 Objective: To evaluate the therapeutic effect of Bonin (Disodium Pamidronate) for bone metastases of lung cancer Methods: Using a randomized clinical study of Bonin with radiotherapy Results: The overall effective rate of Bonin for bone pain in the 40 patients with bone metastases of lung cancer was 875%, the complete response was 500%as compared to the RR of 846%in the Bonin therapy alone group and 916%in the combination group of Bonin with radiotherapy and 867%in the combination group of Bonin with chemotherapy The differences were not statistically significant (P >005) The effective rate of radiotherapy alone for bone pain in the 40 patients with bone metastases of lung cancer was 825%, the complete response rate was 350% Very mild gastrointestinal side-effects such as nausea in the Bonin therapy group were observed Conclusion: Bonin is a generation of bisphosphonates and could be used in patients with bone metastases from lung cancer in combination with radiotherapy and chemotherapy更多还原