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造血干细胞移植治疗中高度恶性非霍奇金淋巴瘤5例

Five Cases of Intermediate-Grade and High-Grade Non-Hodgkins Lymphomas Treated with Hematopoietic Stem Cell Transplantation

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【作者】 吴祥元林曲黄仁魏林东军夏忠军

【Author】 Wu Xiangyuan Lin Qu Huang Renwei et al Department of Internal Medicine, Third Hospital of Sun Yat-Sen University of Medical Sciences, Guangzhou

【机构】 中山医科大学附属第三医院内科

【摘要】 造血干细胞移植治疗非霍奇金淋巴瘤(NHL)5例,包括4例第一次完全缓解(CR)中、高度恶性NHL;1例(CR)高度恶性NHL合并淋巴瘤白血病。其中自体骨髓移植(ABMT)4例,异基因外周血干细胞移植(alo-PBSCT)1例。所有病例均移植成功。4例ABMT患者已无病生存50、48、39和3个月,1例alo-PBSCT发生慢性移植物抗宿主病(cGVHD),移植后12个月死于白血病复发。结果显示ABMT是治疗中、高度恶性NHL有效手段。

【Abstract】 Five patients with Non-Hodgkins lymphoma (NHL) were treated with hematopoietic stem cell transplantation, including 4 cases of intermediate-grade and high-grade NHL, one case of high-grade NHL leukemia in complete remission Among them 4 patients were treated with autologous bone marrow transplantation (ABSCT), one patient with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) The hemapoietic function of all patients were recovered and had good engraftment Four patients with ABMT were NHL free survivors for 50,48, 39 and 3 months One case of allo-PBSCT presented cGVHD, but died of relapse in 12+months post-PBSCT The result indicated that ABMT is effective in the treatment of intermediate-grade and high-grade NHL

  • 【文献出处】 中国肿瘤临床 ,CHINESE JOURNAL OF CLINICAL ONCOLOGY , 编辑部邮箱 ,1999年06期
  • 【分类号】R733.105
  • 【下载频次】38
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