【摘要】 目的：探讨ｐ５３、ｎｍ２３蛋白与甲状腺癌临床生物学行为及预后的关系。方法：应用免疫组化法对８６例甲状腺癌标本进行ｐ５３、ｎｍ２３蛋白检测，并对这些病例进行回顾性分析。结果：甲状腺癌中ｐ５３蛋白阳性率３３．７２％；各病理类型间阳性率差别无统计学意义；ｐ５３蛋白阳性率与肿瘤局部侵犯程度、远处转移呈正相关；与患者１０年生存率呈负相关；与淋巴结转移无统计学相关性。甲状腺癌中ｎｍ２３蛋白细胞浆。细胞核表达阳性率分别为７６．７４％和２７．９０％；各病理类型间差别无统计学意义；除ｎｍ２３蛋白核表达阳性与甲状腺癌的远处转移呈负相关外，ｎｍ２３蛋白细胞浆、核表达阳性率与肿瘤浸润程度、淋巴结转移及预后均无统计学相关性。ｐ５３和ｎｍ２３蛋白表达在甲状腺癌中亦无统计学相关性。结论：ｐ５３蛋白阳性在甲状腺癌中提示肿瘤有较强的局部侵袭力和远处转移能力，是预后不良的标志；ｎｍ２３蛋白核阳性提示肿瘤不易出现远处转移，与ｐ３３蛋白检测结合可估计患者预后。更多还原

【Abstract】 Objective: To study the relationship between p53, nm23 protein and the biological behav-ior and prognosis of thyroid cancer. Methods: Eighty - six cases of thyroid cancer were studied immunohis-tochemically. Results: The positive rate of p53 was 33. 72% . Higher positive rate of p53 was observedin patients with deeper invasion ( P < 0. 01 ) and distant metastasis ( P < 0. 005), and it was negativelycorrelated with the 10 - year survival (P< 0. 005) . The nm23 protein cytoplasmic and nuclear stainingwere 74% and 27. 9% respectively. The difference of the various pathologic types of the tumor was notsignificant statistically. Besides nm23 nuclear staining was negatively correlated with distant metastasis.No statistic significance was observed between positive expressions of nm23 cytoplasmic and nuclear pro-tein and the invasiveness, lymphatic metastasis and prognosis of the disease as well. There was no relation-ship what so ever between the expression of p53 and nm23 protein in thyroid cancers- Conclusion: It isvaluable to determine p53 and nm23 protein in thyroid cancers.更多还原