【摘要】 目的 :探讨乳腺浸润性小叶癌PCNA、p5 3的表达及意义。 方法 :采用免疫组化S -P法 ,对 5 4例浸润性小叶癌进行检测 ,用有关统计学方法结合随访资料进行分析。结果 :浸润性小叶癌PCNA阳性率为 90 74% (49/5 4) ,PCNA平均指数 5 1 5 0 %± 2 2 49% ,PCNA指数与临床分期、淋巴结转移有密切关系 (P <0 0 1)。随PCNA指数升高 ,浸润性小叶癌患者生存期缩短 (P <0 0 1)。但浸润性小叶癌p5 3阳性率仅为 3 70 % (2 / 5 4)。结论 :1)PCNA可作为反映浸润性小叶癌增殖活性 ,预测预后的重要指标。 2 ) p5 3免疫组化检测不能作为浸润性小叶癌的有用指标 ,需探讨其它的检测方法。 3)进一步显示浸润性小叶癌与来源于导管上皮的乳腺癌的某些生物学特征可能不同。更多还原

【Abstract】 Objective: To study the expression of proliferating cell nuclear antigen (PCNA) and p53 in breast infiltrating lobular carcinoma (ILC) and its clinicopathological signification Methods: PCNA and p53 expression in 54 cases of ILC were determined with S-P immunohistochemical method Results:It was shown that the positive rate of PCNA in ILC was 90 74%(49/54) The mean PCNA index (PI) was 51 50 %±22 49% The PI was closely correlated with the clinical stage, lymph node involvement ( P < 0 01) The higher the PI was, the shorter survival rate was in the ILC of breast ( P < 0 01), but the positive rate of p53 was only 3 70%(2/54) Conclusion:These suggest that 1) Immunohistochemical determination of PCNA in ILC is a reliable and important indicator for assessing proliferating activity and predicting prognosis of the patient 2)S-P immunohistochemical determination of p53 gene is not appropriate for assessing ILC and other methods should be used 3) The biological features may be different between ILC and breast cancer derived from ductal epithelial cell更多还原