【摘要】 目的 :研究超抗原抗肿瘤机理并评价SEA对T739小鼠膀胱癌的抑癌效应。方法 :采用已建立T739小鼠皮下可移植性膀胱肿瘤模型 ,实验组在移植瘤处局部注射SEA ,对照组应用生理盐水 ,观察治疗后各组的肿瘤重量和存活时间。结果 :SEA组小鼠肿瘤重量 (0 .6 5± 0 .18g)明显低于对照组 (4.2 8± 0 .86 g) ,抑瘤率为 84.7% (P <0 .0 1) ,SEA组小鼠存活期 (2 3.1± 2 .74天 )比对照组 (18.6± 1.5 0天 )延长 (P <0 .0 1) ,存活延长率为 2 4.1%。结论 :超抗原做为一种新的抗肿瘤生物制剂有明显的抑癌效应。更多还原

【Abstract】 Objective:To study the anti-tumor mechanism of superantigen and to evaluate the anti-bladder-tumor effect of staphylococcal enterotoxin A (SEA) in mice. Methods: We produced a subcutaneous tumor model in T739 mice by implanting BTT739 bladder transitional cell cancer cells in syngeneic mice. The EA was locally injected to the mice at the site of implant in the trial group, and normal saline to the control group mice only. The weight of the tumor and the survival were recorded after treatment. Results: The average weight of tumors in the trial group (0.65±0.18g) was lower than that of the control group (4.28±0.86g) ( P < 0.01). The tumor inhibition rate of the trial group was 84.7%, and the mean survival period of SEA group (23.1±2.47d) was longer than that of the control group (18.6± 1.50d ) ( P < 0.01) with a survival prolongation rate of 24.1%. Conclusion: The results indicate that superantigen has an obvious anti-bladder -tumor effect in T739 mice.更多还原