【摘要】 目的：正常组织的放射损伤是限制肿瘤获得足量放射治疗的主要原因，进而影响到患者的放射疗效。本研究旨在观察β－ｃａｒｏｔｉｎｅ 对小鼠正常皮肤，小肠和免疫细胞放射和（ 或）加温治疗损伤的保护作用。方法：纯系ＴＡⅡ小鼠分为１１ 组，β－ ｃａｒｏｔｉｎｅ 每日每只灌服４ｍｇ，隔日１ 次；Ｘ 线直线加速器１０Ｇｙ 单次照射，４３．５ ℃水浴加温４５ 分钟。分组治疗后分别观察皮肤，肠粘膜反应及Ｔ 细胞水平。结果：①β－ ｃａｒｏｔｉｎｅ 对皮肤，肠粘膜和免疫细胞均有不同的放射和（或） 加温损伤的保护作用，而治疗前后均给予β－ ｃａｒｏｔｉｎｅ 组作用显著；②１０Ｇｙ 照射使ＣＤ４／ＣＤ８ 从对照组的１．５０降到０．８４ ，放射治疗前后给予β－ ｃａｒｏｔｉｎｅ，使ＣＤ４／ＣＤ８ 回升到１．３１ 。结论：β－ｃａｒｏｔｉｎｅ 保护正常组织放射和（ 或） 加温操作的作用主要出现在β－ｃａｒｏｔｉｎｅ 较高的血浆水平。更多还原

【Abstract】 The protective effect of β-carotine against radiation and/or hyperthermia damage to skin, intestinal mucosa and immune cells of TAII mice were observed. Inbred TAII mice were divided into 9 groups. β-carotine (4mg) was given orally to the mouse every other day. The single dose of 10Gy radiation, and water bath of 43.5℃heated for 45 minutes(RH group) were given. The reaction of skin, intestinal mucosa and the number of T cell were observed and determined. The results showed that: 1) The protective effect of β-carotine on skin, intestinal mucosa and immune cells against radiation and/or hyperthermia could be seen in various extent, and significant effect was only found in β-RH-βgroup. 2) Prominent protective effect was mainly found in the mice with higher plasma level of β-carotine. 3) The level of CD4/CD8 in the control group decreased from 1.50 to 0.84. In 10Gy radiation group, the ratio of CD4/CD8 increased to 1.31 as the β-carotine was given before and after RH.更多还原