【摘要】 目的观察放化疗同步及序贯治疗中晚期食管癌的疗效。资料与方法１９９２年６月至１９９７年６月，采用随机分组对１４０例食管癌进行放化同步及序贯治疗，并与１１８例单纯放射治疗结果进行对比。结果放化疗同步组、放化疗序贯组有效率为９１％和８３．３％，单纯放射治疗组７５．７％（Ｐ＜０．０５）；前两组１、２年生存率为８２％、５２％和８０％、４７％，后组为５１％、２７％（Ｐ＜０．０５）。中位生存期放化疗同步组与序贯组为１７．５与１４．５个月，单纯放疗组为８．６个月。前两组局部复发率、远处转移率均明显低于后组。结论放化疗同步、序贯治疗中晚期食管癌与单纯放射治疗组相比可明显提高有效率，１、２年生存率及中位生存期，并可降低局部复发率及远处转移率，但对３、４年生存率未见明显优势。更多还原

【Abstract】 Objective To observe the effect of chemotherapy combined with radiotherapy concurrently or sequentially and radiotherapy alone.Methods Two hundred and fifty-eight patients with advanced esophageal carcinoma(from June 1992 to June 1997) were randomized to 3 groups:radiotherapy alone (group 1), chemotherapy combined with radiotherapy concurrently (group 2) and chemotherapy combined with radiotherapy sequentially (group 3).Group 1:118 cases were irradiated with 60 Co routine three fields,DT65Gy-70Gy/65-7weeks.Group 2:70 cases bean to irradiat with 60 Co routine three fields,on the first day of chemotherapy (DF),with 60 Co routine three fields,DT50Gy-55Gy/5-6weeks and were treated with HDR introcavitary radiotherapy after two weeks,DT10Gy.Group 3:70 cases were treated with chemotherapy at first and were irradiated 2wddks later.the methods of radiotherapy was the same as group 2.Results The 1 and 2 years survival rates in group 2 and group 3 were 82%,52% and 80%,47% respectively.The 1 and 2 years survival rates in group 3 were 51% and 27%.Conclusions Chemotherapy combined with radiotherapy concurrently or sequentially have better dffect than radiotherapy alone.更多还原