【摘要】 目的通过回顾研究，比较支撑架植入术后放化疗和非放化疗对晚期食道癌患者生存率的影响。方法1996年2月至1999年1月，37例晚期食道癌患者因食道癌引起的吞咽困难行食道支撑架植入术。术前进行临床和影像学检查。对植入术前后的吞咽能力进行评分，对术后放化疗组生存率的影响进行分析。结果34例病人的吞咽困难症状得到改善，4例病人手术中需植入2个支撑架，其中2例因病变部位长，2例支撑架植入位置不良，8例病人平均随访时间125.25士28．07天，由于术后吞咽困难加重需植入第二个支撑架，术后37例平均生存时间175．27士77．13天，进行术后放化疗组病人（n=17）生存期相对延长，诊断后平均生存期261．52士58．59天，较非放化疗组平均生存时间为144.3土41．64天（P＜0·001）。结论晚期食道癌支撑架植入术结合术后的放化疗可以改善病人的生存时间。更多还原

【Abstract】 The aims of this retrospective study were to cornpare the survival time of the patients suffering from unresectable esophageal carcinoma treated by mesh stents with or with out radiochemotherapy. Methods From April 1996 to January 1999, 37 patients with advanced esophageal carcinoma were treated with esophageal Mesh stents because their symptorn of dysphagia. Clinical and imaging examinations were perforrned before stent implantation. Survival rates of these patients were analyzed with regard to their degree of dysphagla and the effect of additional radiation and chemotherapy. Results Following stent placement dysphagia had been improved in 34 out of 37 patients. Four patients required second stent implantatlon during operation due to the lengthy lesions (N= 2) or displacement of stents (N = 2). The second stent implantation to alleviate worsening dys phagia were necessary in 8 patients during an average follow-up period of 125. 25 f 28. 07 days. Pa tients receiving concurrent radiation and chemotherapy. (n = 17 ) experienced prolonged survival (a mean survival time 261. 52 58. 59 days after diagnosis ) compared to patients without additional therapy (n = 20, 144. 30 41. 64 days after diagnosis, P<0. 001 ). Conclusions The combination of stenting with additional radiation and chemotherpay was correlated with the prolonged survival of pa tients.更多还原