【摘要】 目的：探讨不同剂量的中药黄芪对顺铂所致肾毒性的防护作用，以期指导临床改变目前高剂量顺铂必须水化的现状。方法：以７ ｍｇ·ｋｇ－１ 顺铂单次腹腔注射建立小鼠的肾损模型，于实验的第１～７ 天分别给予不同剂量的黄芪腹腔注射。评估小鼠血尿素氮、血肌酐、血ＮＡＧ酶及肾脏病理学改变。同样的方法实验Ｓ１８０ 荷瘤小鼠并评估瘤重。结果：不同剂量的黄芪均能明显改善顺铂所致小鼠血尿素氮、血肌酐、血ＮＡＧ酶的增高，并与黄芪的剂量正相关。但当黄芪剂量增加到一定数值，其保护作用稳定，对顺铂的抗肿瘤活性均无影响。获病理学支持。结论：黄芪确能防护顺铂所致的肾毒性且不影响其抗瘤活性更多还原

【Abstract】 OBJECTIVE:The aim of the present study is to evaluate whether astragalus membranaceus(AM) can ameliorate alteration nephrotoxicity by cisplatin in animal models.It is possible to administrate much high dose of cisplatin without large venoclysis in clinic.METHODS:Mice were induced by a single injection of cisplatin(7 mg·kg -1 ip).Different AM dose(0～30 g·kg -1 ) was injected intraperitoneally from 1 to 7 day.Blood urea nitrogen,blood creatinine and N aceyl beta D glucisaminidase(NAG) were measured.On both of the investigated models renal pathomorphology was detected.Mice inoculated S 180 tumor cells were measured by the same procedure and tumor weight was evaluated.RESULTS:The increase of blood urea nitrogen,blood creatinine,NAG in mice could be improved markedly by different AM dose.It was also supported by renal pathomorphology that AM could reduce the cisplatin induced nephrotoxicity.AM treatment did not result in any observable loss in anti tumor activity of cisplatin.CONCLUSIONS:These data from the basis supposed that AM can protect nephrotoxicity induced by cisplatin without reducing its anti tumor activity.It will be worthy of further clinical trial.更多还原