【摘要】 目的：研究泮托拉唑钠的合成方法。方法：以５二氟甲氧基２巯基１Ｈ苯并咪唑和２氯甲基３，４二甲氧基吡啶盐酸盐为原料，经缩合，氧化，成盐三步反应合成泮托拉唑钠。结果：所选路线制备泮托拉唑的总产率为７７２％，结构经ＩＲ，ＵＶ，ＮＭＲ和元素分析确证。结论：所选路线简便易行，是合成泮托拉唑钠的较好方法。更多还原

【Abstract】 OBJECTIVE: To study on the synthesis of pantoprazole sodium METHODS: Pantoprazole sodium was synthesized from 5difluoromethoxy2mercapto1Hbenzimidazole and 2chloromethyl3,4dimethoxypyrdine hydrochloride RESULTS: The total yield of synthetic pantoprazole sodium was 772% The final product was identified by IR, UV, MS and NMR, respectively CONCLUSION: It is a better way to prepare pantoprazole sodium with a relative high yield更多还原