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结肠靶向性高分子——甲基丙烯酸甲酯—甲基丙烯酸共聚物理化性质的研究

Colontargeting polymers a study of physical and chemical properties of PMMAcoMAA

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【作者】 郭圣荣傅崇东刘罡一廖荣平徐惠南

【Author】 Author Guo Shengrong(Guo SR),Fu Chongdong (Fu CD),Liu Gangyi (Liu GY), et al (Department of Pharmaceutics,Shanghai Medical University,Shanghai 200032)

【机构】 上海医科大学药剂学教研室

【摘要】 目的:制备具有不同酸值的甲基丙烯酸甲酯甲基丙烯酸共聚物(PMMAcoMAA),研究其理化性质以便评估其结肠靶向性。方法:以PMMAcoMAA薄膜为对象,研究薄膜的水渗透性、溶胀性、临界溶解pH和在不同pH缓冲液中的稳定性。结果:PMMAcoMAA的理化性质差异是它们的酸值不同导致的,PMMAcoMAA酸值越小,其临界溶解pH越大。结论:PMMAcoMAA的理化性质取决于它们的酸值大小。

【Abstract】 BJECTIVE: Several copovymers of methyl methacrylate (MMA) and methacrylic acid(MAA) as potential coatings for colon delivery.HZMETHODS: Water vapor transimission,swelling characteristics,in vitro dissolution and stability in function of pH were investigated using the technique of isolated films. RESULTS: The data presented demonstrate relative differences in physicochemical characteristics duo to differences in acid value.The lower acid value is ,the higher critical dissolution pH is. CONCLUSION: The physicochemical properties of PMMAcoMAA are highly influenced by their acid values.

  • 【文献出处】 中国药学杂志 ,CHINESE PHARMACEUTICAL JOURNAL , 编辑部邮箱 ,1999年07期
  • 【分类号】R914.3
  • 【被引频次】6
  • 【下载频次】183
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