【摘要】 目的：研究缺氧性肺动脉高压（ＨＰＨ）大鼠血浆降钙素基因相关肽（ＳＣＧＲＰ）水平，ＣＧＲＰ及碱性成纤维细胞生长因子（ｂＦＧＦ）、血小板源性生长因子（ＰＤＧＦ）在肺内表达和川芎嗪（ｌｉｇｕｓｔｒａｚｉｎｅ，Ｌｉ）对其影响。方法：建立ＳＤ大鼠常压ＨＰＨ模型；用酶联免疫检测技术测定ＳＣＧＲＰ水平；用免疫组化染色检测ＣＧＲＰ，ＰＤＧＦ，ｂＦＧＦ在肺内表达水平。结果：缺氧（Ｈ）组大鼠ＳＣＧＲＰ较正常对照（Ｎ）组明显下降，Ｐ＜０．０１；缺氧加川芎嗪（Ｈ＋Ｌｉ）组ＳＣＧＲＰ水平较Ｈ组无显著性差异，Ｐ＞０．０５；免疫组化染色显示Ｈ组ＣＧＲＰ，ｂＦＧＦ，ＰＤＧＦ的肺内表达均显著增强，而Ｈ＋Ｌｉ组ｂＦＧＦ，ＰＤＧＦ表达水平与Ｈ组比较明显降低，但ＣＧＲＰ表达不受Ｌｉ影响。结论：ＨＰＨ的形成与ＳＣＧＲＰ下降和肺内ＰＤＧＦ，ｂＦＧＦ表达增强有关；Ｌｉ抑制缺氧大鼠肺内ＰＤＧＦ和ｂＦＧＦ表达是其防治ＨＰＨ的机制之一。更多还原

【Abstract】 OBJECTIVE:To study the effects of ligustrazine on the SCGRP and on the expression of CGRP,PDGF and bFGF in the lung of CHPH rats.METHOD:A stable rat modle of CHPH was established.The serum CGRP levels were mesured by enzyme immunoassay.The expression of CGRP,PDGF and bFGF in lumg were observed by immunohistochemical method.RESULTS:①The SCGRP level of H group was significantly lower than that of N group ( P <0.01) but no difference between the H+Li group and H group ( P >0.05).②The expression of CGRP,PDGF and bFGF increased obviously in lung tissue of H group,whereas the expression of bFGF and PDGF of H+Li group reduced obviously but that of CGRP was not influenced.CONCLUSION:SCGRP reduction and expression increasion increasion of PDGF.bFGF have close relation with the formation of CHPH;Inhibiting the expression of PDGF.bFGF may be an aspect of the mechanism of preventing and treating HPH by ligustrazine.更多还原