【摘要】 目的：探讨辅酶Ｑ１０ 及山莨菪碱对培养心肌细胞缺氧复氧的作用机制。方法：观察培养液中ＬＤＨ 和ＣＰＫ－ＭＢ含量，细胞内ＭＤＡ、ＳＯＤ和ＧＳＨ－ＰＸ的活性变化。结果：辅酶Ｑ１０ 和山莨菪碱可减少氧自由基产生。结论：氧自由基是造成心肌细胞缺氧复氧损伤的重要原因；辅酶Ｑ１０和山莨菪碱能保护心肌细胞内ＳＯＤ及ＧＳＨ－ＰＸ的活性更多还原

【Abstract】 Objective:Mechanism of coenzyme Q 10 & antisodamine against myocardial hypoxia/reperfusion injury was studied by using hypoxic model of cultured rat myocardial cell.Methods: Changes in concentrations of LDH, CPK-MB, MDA,SOD, and GSH-PX activity of the cultured myocardial cell were observed during the process of experiment. Results: Oxygen free radical was one of the main causes of hypoxia/reoxygenation injury. Conclusion:Anisodamin & coenzyme Q 10 can lessen the rate of the oxygen free radical generation and protect the activity of SOD and GSH PX.更多还原