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原因不明性肝炎血清TTVDNA的检出和意义

Detection of TTV Infection and Clinical Investigation in Patients with Hepatitis of Unknown Etiology

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【作者】 舒波; 窦晓光; 刘沛; 黄敦武; 王兆荃;

【Author】 Shu Bo, Dou Xiaoguang, Liu Pei, et al (Department of Infectious Diseases, The Second Clinical College, China Medical Unviersity, Shenyang, 110003)

【机构】 中国医科大学第二临床学院传染科!沈阳110003; 解放军第202医院;

【摘要】 目的:调查原因不明性肝炎的TTV感染状况。方法:设计TTV基因的特异性引物,应用PCR反应检测48 例原因不明性肝炎血清中的TTV DNA。结果:48例原因不明性肝炎中13 例TTV DNA阳性(27.1% ),其中急性肝炎9 例,慢性肝炎3 例,亚急性重型肝炎1例。结论:TTV感染是原因不明性肝炎的致病因子,TTV 感染能引起急性、慢性以及重型肝炎

【Abstract】 Objective: We investigated investigate the presence of TTV infection among patients with hepatitis of unknown etiology. Methods: Forty eight serum samples from patients with hepatitis of unknown etiology were detected for TTV DNA by PCR methods. Results: The positive rate of TTV DNA accounted for 27.1% (13/48) in patients with hepatitis of unknown etiology. Among 13 patients with TTV DNA positive response, 7 were acute hepatitis, 5 were chronic hepatitis and 1 was subfulminant hepatitis. Conclusion: TTV infection could be associated with occurence of hepatitis, and could result in acute, chronic and fulminant hepatitis.

  • 【文献出处】 中国医科大学学报 ,JOURNAL OF CHINA MEDICAL UNIVERSITY , 编辑部邮箱 ,1999年05期
  • 【分类号】R512.6
  • 【被引频次】1
  • 【下载频次】17
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