【Abstract】 Objective: To compare the effects of primary coronary angioplasty with intravenous thrombolysis after acute myocardial infarction (AMI) on myocardial infarct size and left ventricular function Methods: Forty seven patients with a first AMI underwent either primary coronary angioplasty (15 patients, group A) or intravenous thrombolysis (32 patients) According to clinical early reperfusion parameters, 32 AMI patients were divided into two groups, 19 with reperfusion group (group B) and 13 non reperfusion group (group C) Between one and two weeks after AMI, myocardial infarct size was measured by quantitative technetium 99m sestamibi single photon emission computed tomography combined with isosorbide dinitrate infusion Cardiac function (left ventricular ejection fraction, LVEF) was assessed by echocardiograph during 10～14 days after AMI Results: The myocardial infarct size and LVEF in group A, group B and group C were significiantly different The absolute and relative values of infarct size of group A were smaller than those of group B [(10 46±12 53)cm 2 vs (49 00±28 31)cm 2, p <0 05; (9 13±13 61)% vs (26 62±15 53)%, p <0 05, respectively], and group B were smaller than group C [(49 00±8 31)cm 2 vs (95 69±59 33)cm 2, p <0 05; (26 62±15 53)% vs (51 93±21 10)%, p <0 01), respectively] The LVEF of group A was higher than that of group B [(64 17±8 34)% vs (54 33±12 52)%, p <0 05], and group B was higher than group C [(54 33±12 52)% vs (43 15±6 95)%, p <0 01] Conclusion: In patients with acute myocardial infarction, primary angioplasty results in a smaller infarct size and a better preserved cardiac function compared with patients receiving intravenous thrombolysis更多还原