【摘要】 目的 :研究冠心病患者血浆同型半胱氨酸 (Hcy)水平与颈动脉内膜—中层厚度 (IMT)的关系。　　方法 :运用高效液相色谱仪、荧光检测仪和超声心动图仪测定 31例恶化劳力型心绞痛患者 (为恶化劳力型心绞痛组 )、2 8例陈旧性心肌梗塞患者 (为陈旧性心肌梗塞组 )和 35例正常人 (为正常对照组 )血浆总 Hcy水平和颈动脉 IMT。　　结果 :恶化劳力型心绞痛、陈旧性心肌梗塞患者血浆总 Hcy水平分别为 19.5 3± 6 .0 2 μmol/ L 与 2 6 .35± 10 .48μmol/ L ,均显著高于正常对照组 11.2 4± 2 .31μmol/ L (P<0 .0 0 1)。恶化劳力型心绞痛组和陈旧性心肌梗塞组患者两侧颈总动脉、颈总动脉分叉处和颈内动脉 IMT与正常对照组比较均有显著性差异 (P<0 .0 0 1)。陈旧性心肌梗塞患者血浆总 Hcy水平与左、右侧颈总动脉及右侧颈内动脉 IMT之间有显著的相关性 ,相关系数分别为 0 .5 982 (P<0 .0 1)、0 .475 1(P<0 .0 5 )、0 .4792 (P<0 .0 5 )。　　结论 :陈旧性心肌梗塞组患者血浆总 Hcy水平与颈动脉 IMT相关 ,提示颈动脉 IMT的增厚与血浆 Hcy水平升高的程度一致。更多还原

【Abstract】 Objective:To investigate the relationship between plasma homocysteine (Hcy) level and carotid intimal medial thickness (IMT) in patients with coronary heart disease (CHD). Methods:Thirty one patients with worsening effort angina,28 patients with old myocardial infarction,and 35 normal subjects were recruited to participate the study.Plasma total Hcy levels were measured using high performance liquid chromatography with fluorescence detection and the carotid IMT was studied by using two dimensional echocardiography. Results:Mean plasma total Hcy levels was 11 24±2 31 μmol/L for normal controls;19 53±6 02 μmol/L for worsening effort angina and was 26 35±10 48 μmol/L for old myocardial infarction patients.Statistically,the mean plasma total Hcy levels between normals and CHD patients and between the two patient groups were all significantly different ( p <0 001).Significant differences were found between the IMTs of the common carotids,bifurcations and internal carotids of normal subjects and CHD patients (patients with worsening effort angina and old myocardial infarction).Plasma total Hcy levels were significantly correlated with IMTs of both sides of common carotids,and right internal carotid ( r=0 5982,p <0 01; r=0 4751,p <0 05;r= 0 4792,p <0 05,respectively) in patients with old myocardial infarction. Conclusion:Plasma total Hcy levels are significantly positive correlated with the carotid IMT in old myocardial infarction patients,and the degree of increased carotid intimal medial thickness is consistent with the extent of elevated plasma Hcy levels.更多还原