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口服乐腹康胶囊活菌制剂对人体肠道菌群的影响

EFFECT OF ORAL ADMINISTRATION OF LE-FU-KANG CAPSULAC ON HUMAN INTESTINAL FLORA

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【作者】 周和平查星邓洋国彭农刘波

【Author】 Zhou Heping, et al. Chengdu Institute of Biological Pnoduct Chengdu, 610063 .

【机构】 卫生部成都生物制品研究所

【摘要】 本文报道了口服乐腹康胶囊活菌制剂对正常人体肠道的双歧杆菌、乳杆菌、大肠杆菌等的影响。结果显示口服后,对肠道菌群有短暂(1~2天)抑制生长作用,而后对厌氧菌中的双歧杆菌、乳杆菌有明显促进生长的作用。双歧杆菌在服药前平均为506±103亿/克,服药后10天升至1873±143亿/克,增长370倍(P<005),有显著性差异。乳杆菌服药前平均数为274±025亿/克,服药后10天升至507±121亿/克,增长185倍。而对需氧的大肠杆菌和其他肠道球菌有持续的抑制作用,大肠杆菌服药前平均数为342±021亿/克,服药后10天降至105±009亿/克,仅为原来的30%(P<005),有显著的差异

【Abstract】 This papen describes the effect of oral administration of Le-Fu-Kang caprulae, a live bio-product of Bacillus cereus, on B.bifidus, lactobacillu and E.coli of normal human intestional flora. Results showed that the flora were inthibited for the first 1-2 days and the growth of B.bilidus and lactobacilli markedly increased afterwards. The number of B.bifidus averaged 1.73×10 8p.f.u./g at 10 days after administration, or 2.58 times as many as before taking the medicine, and the difference was signibicant (P<0.01) when compared with the number before taking the medicine. Likewise, in the case of lactobacillus, the number increased to 2.812×10 8/g, or 1.5 times as many as beore taking the modicine. On the contrary, in the caseof E.coli as well as enterococci, these organisms were persistently suppnessed. For E.coli, the number was 1.054×10 8p.f.u/g, or decreased by 70% when compared with the number before taking the medicine.

  • 【文献出处】 中国微生态学杂志 ,CHINESE JOURNAL OF MICROECOLOGY , 编辑部邮箱 ,1999年01期
  • 【分类号】R979.9
  • 【被引频次】1
  • 【下载频次】30
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