【摘要】 目的　探讨微血管密度（ ＭＶＤ） 与胃癌复发转移及预后的相关性。方法　４５ 例手术切除标本应用ＦⅧ相关抗原抗体免疫组化染色，观察癌灶、癌旁及正常组织中ＭＶＤ，分析其与复发转移及预后的关系。结果　ＭＶＤ 在癌组织为３８－１２ ±１２－８７ ，癌旁为２４－６７ ±１１－０９，正常组织为１３－１１ ±７－５６（ Ｐ＜ ０－０５） 。复发转移组和无复发转移组的ＭＶＤ 分别为３８－３１ ±９－６７ 和２１－９８ ±１２－２３（ Ｐ＜ ０－０１） 。两组在淋巴结转移、浸润深度、肿瘤分期三方面差异也有显著性（ Ｐ＜ ０－０５） 。结论　微血管的生长与肿瘤的血行和淋巴结转移有关。除淋巴结转移、浸润深度、肿瘤分期具有预后意义外，胃癌组织中ＭＶＤ 也具有判断预后价值。更多还原

【Abstract】 Objective To study microvessel density(MVD) in gastric cancer in relation to cancer recurrence or metastasis and prognosis.Methods MVD in 45 specimens resected from patients with gastric cancer was investigated by immunohistochemical staining with a monoclonal antibody against FⅧ related antigen.Results The mean MVD was 38 12±12 87 in tumor,24 67±11 09 in tumor-adjacent and 13 11±7 56 in normal tissue(P<0 05).The MVD in patients with cancer recurrence or metastasis was 38 31±9 67 which was significantly greater than that in patients without cancer recurrence or metastasis which was 21 98±12 23(P<0 01).The lymph mode metastasis,depth of invasion,stage of the tumor were all significantly different between the 2 groups(P<0 05).Conclusion MVD was related to lymph node metastasis and hematogenous dissemination of gastric cancer.Besides lymph node metastasis,depth of invasion,stage of the tumor,MVD was also of prognostic significance.更多还原