【摘要】 目的　探讨ＥＭＡ－ ＣＯ 方案治疗高危、耐药妊娠滋养细胞肿瘤的疗效和可行性。方法　统计ＥＭＡ－ＣＯ方案治疗３３ 例妊娠滋养细胞肿瘤的疗效、毒副反应和化疗剂量强度的实施情况。结果　总有效率７８－７８％（２６／３３） ，高危组有效率８８－２３ ％（１５／１７） ，耐药组有效率７３－３３％ （１１／１５）；主要毒副反应为骨髓抑制和胃肠道反应，未发生致死毒副反应；按计划实施剂量强度疗程数占５２－６３％ ，影响剂量强度主要因素是骨髓抑制、病人恐惧等。结论　ＥＭＡ－ ＣＯ方案是治疗高危、耐药妊娠滋养细胞肿瘤安全、有效的方案，为保证按计划实施化疗剂量强度，可预防性使用细胞因子和抗吐。更多还原

【Abstract】 Objective\ To evaluate the acceptability and effectiveness of EMA-CO regime on treatment of gestation trophoblastic neoplasms.Methods\ The effectiveness,side effect and chemotherapy dose intensity of this regime were analyzed in 33 cases.Results\ The effectiveness of the regime was 78.78%(26/33)for average,88.23%(15/17)for high risk group,and 73.33%(11/15)for resistance group.The bone marrow toxicity and gastrointestinal reaction were the main side effects.No fatal effect was found.52.63% were treated with the planned dose intensity.The main factors for failure with the planned dose intensity were bone marrow toxicity and fear of patients.Conclusions\ The EMA-CO regime was an effective and safe method for therapy of high risk and drug resistance gestation trophoblastic neoplasms.The application of cytokine and antiemetic therapy may improve the use of the regime with planned chemotherapy dose intensity.更多还原