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口服青蒿琥酯对伯氏鼠疟和诺氏猴疟的杀灭效果<英文>
Schizontocidal effects of oral artesunate on Plasmodium berghei in mice and P knowlesi in monkeys
【摘要】 目的:研究青蒿琥酯口服对伯氏鼠疟和诺氏猴疟的血液裂殖体杀灭效果。方法:分别在鼠疟和猴疟模型上采用“4-day试验法”、“28-day试验法”和“7-day试验法”检测了青蒿琥酯和氯喹的药效。结果:口服青蒿琥酯对伯氏鼠疟民K173株的抑制效果低于氯喹,但其原虫血症下降50%、90%和转阴的时间比氯喹快10-15h,对抗株RC/K173的疗效优于氯喹,无交叉抗性,I90仅为1.4。青蒿琥酯和氯喹对诺氏猴疟在31.6,10.0和3.16mg·kg-1剂量组的试验猴全部治愈。结论:口服青蒿琥酯在鼠、猴疟模型上的药效研究为临床研究提供有益参考。
【Abstract】 AIM: To study the blood schizontocidal effect of oral artesunate on P berghei in mice and P knowlesi in monkey. METHODS: Effects of artesunate and chloroquine were detected with "4-day test" and "28-day test"on P berghei in mice and "7-day test" on P knowlesi in Macaco, mudatta. RESULTS: The suppressive efficacy of oral artesunate was inferior to chloroquine on P berghei K173 strain but the time for 50 % and 90 % reduction and the time of clearance of parasitemia was 10 - 15 h shorter than that of chloroquine. Its curative effect on RC/K173 line was markedly superior to that of chloroquine. Moreover, artesunate showed no cross-resistance with chloroquine, index of resistance I90 was only 1.4. At 31.6, 10.0, and 3.16 mg·kg-1, artesunate and chloroquine oral administrations cured P knowlesi in all monkeys. Recrudescence did not occur in 105 d. CONCLUSION: The study of effects of oral artesunate in P berghei/mice and P knowlesi/Macaca mulatta model provided a useful index for clinical trial.
【Key words】 artesunate; chloroquine; Plasmodium berghei; Plasmodium knowles; antimalarials;
- 【文献出处】 Acta Pharmacologica Sinica ,中国药理学报(英文版) , 编辑部邮箱 ,1999年08期
- 【分类号】R96
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