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口服青蒿琥酯对伯氏鼠疟和诺氏猴疟的杀灭效果<英文>

Schizontocidal effects of oral artesunate on Plasmodium berghei in mice and P knowlesi in monkeys

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【作者】 时云林李国福赵京花杨俊德丁德本

【Author】 SHI Yun-Lin, LI Guo-Fu, ZHAO Jing-Hua, YANG Jun-De, DING De-Ben( Laboratory of Antimalarial Drug Research , Institute of Microbiology and Epidemiology ,Academy of Military Medical Sciences, Beijing 100071, China)

【机构】 军事医学科学院微生物流行病研究所军事医学科学院微生物流行病研究所 北京 中国 100071北京 中国 100071北京 中国 100071

【摘要】 目的:研究青蒿琥酯口服对伯氏鼠疟和诺氏猴疟的血液裂殖体杀灭效果。方法:分别在鼠疟和猴疟模型上采用“4-day试验法”、“28-day试验法”和“7-day试验法”检测了青蒿琥酯和氯喹的药效。结果:口服青蒿琥酯对伯氏鼠疟民K173株的抑制效果低于氯喹,但其原虫血症下降50%、90%和转阴的时间比氯喹快10-15h,对抗株RC/K173的疗效优于氯喹,无交叉抗性,I90仅为1.4。青蒿琥酯和氯喹对诺氏猴疟在31.6,10.0和3.16mg·kg-1剂量组的试验猴全部治愈。结论:口服青蒿琥酯在鼠、猴疟模型上的药效研究为临床研究提供有益参考。

【Abstract】 AIM: To study the blood schizontocidal effect of oral artesunate on P berghei in mice and P knowlesi in monkey. METHODS: Effects of artesunate and chloroquine were detected with "4-day test" and "28-day test"on P berghei in mice and "7-day test" on P knowlesi in Macaco, mudatta. RESULTS: The suppressive efficacy of oral artesunate was inferior to chloroquine on P berghei K173 strain but the time for 50 % and 90 % reduction and the time of clearance of parasitemia was 10 - 15 h shorter than that of chloroquine. Its curative effect on RC/K173 line was markedly superior to that of chloroquine. Moreover, artesunate showed no cross-resistance with chloroquine, index of resistance I90 was only 1.4. At 31.6, 10.0, and 3.16 mg·kg-1, artesunate and chloroquine oral administrations cured P knowlesi in all monkeys. Recrudescence did not occur in 105 d. CONCLUSION: The study of effects of oral artesunate in P berghei/mice and P knowlesi/Macaca mulatta model provided a useful index for clinical trial.

  • 【文献出处】 Acta Pharmacologica Sinica ,中国药理学报(英文版) , 编辑部邮箱 ,1999年08期
  • 【分类号】R96
  • 【下载频次】1
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