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Regulating effect of carbonic anhydrase (CA) inhibitor on aquaporin-1 (AQP1) water channel gene expression in rat kidney

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【Author】 ZHANG Peng MU Sheng-Mei YU He-Ming LI Xue-Jun ( Department of Pharmacology, Beijing Medical University, Beijing 100083; National Research Institute for Family Planning, Beijing 100081, China)

【机构】 Department of Pharmacology； Beijing Medical University； Beijing 100083； National Research Institute for Family Phanning； Beijing 100081； China； Beijing 100083；

【摘要】 <正> AIM: To investigate whether the aquaporin-1 (AQR-1) geneexpression can be regulated by acetazolamide, a carboincanhydrase inhibitor in rat kidney. Carbonic anhydrase inhibitor isone of the diuretics with the site of action on renal proximaltubules. And AQP-1 wate channel is located on the epithelialcells of the renal proximal tubules with the function of facilitatingwater transport across proximal tubules epithelia. METHODS:The kidneys were excised from immature (20 d) female rat at更多还原

【关键词】 aquaporin； AQP1； CA； proximal； epithelia； immature； excretion； inhibited； reversed； consensus；

【文献出处】 Acta Pharmacologica Sinica ,中国药理学报(英文版) , 编辑部邮箱 ,1999年07期

【分类号】R96
【被引频次】1
【下载频次】7

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