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血源乙型肝炎疫苗免疫持久性观察

Observation on Immune Persistence of the Plasma-derived Hepatitis B Vaccine

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【作者】 蒋丽萍; 孔祥生; 马重义;

【Author】 JIANGLi-ping; KONG Xiang-sheng; MA Chong- Vi.( Epidemic Prevention Station of ChennjiangCounty, Yunnan Province, Chennjiang County 652500, China.)

【机构】 云南省澄江县卫生防疫站!澄江县; 652500;

【摘要】 为了解血源乙型肝炎(乙肝)疫苗的免疫持久性,对澄江县1991~1995年按照0、1、6个月免疫程序完成血源乙肝疫苗接种的人群,按接种后间隔1~5年分组,每组随机抽取100名儿童,采末梢血,共得517份免疫者的血清样品.用酶联免疫吸附试验(ELISA)检测抗-HBs、HBsAg。结果表明,接种乙肝疫苗2年内抗-HBs阳性率在90%以上,以后随间隔年眼的延长而明显下降,间隔5年降至60%,人群平均保护率达78.57%.

【Abstract】 In order to observe the immune persistence of plasma-derived hepatitis Bvaccine in newborns in 1991~1995 in Chengjiang County, the infants were vaccinatedwith plasma-derived hepatitis B vaccine by the schedule of 0, 1, 6, months. 100 infantswere randomy selected for testing serum HBsAg and anti-HBs every year since 1991 byELISA. Altogether 517 blood samples were collected. The anti-HBs positive rate wasabove 90% and henceforth decreased obviously following the passing of the year, untilreaching 60% of the fifth year. The protective rate of the vaccinated infants was 78.57%.

【关键词】 乙型肝炎疫苗; 抗-HBs; 免疫持久性;
【Key words】 Hepatitis B vaccine; Anti-HBs; Immune persistence;
  • 【文献出处】 中国计划免疫 ,CHINESE JOURNAL OF VACCINES AND IMMUNIZATION , 编辑部邮箱 ,1999年05期
  • 【分类号】R186
  • 【下载频次】17
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