【摘要】 目的探讨５－氨基酮戊酸（ＡＬＡ）光动力学疗法（ＰＤＴ）治疗Ｂｏｗｅｎ病的疗效。方法５例Ｂｏｗｅｎ病患者皮损发生于腹部及股部，面积３．２ｃｍ×３０ｃｍ至４．５ｃｍ×３０ｃｍ，均经病理组织学检查确诊。局部外用新鲜配制的２０％ＡＬＡ霜，３ｈ后用波长６３２．８ｎｍ的ＨｅＮｅ激光照射，激光机输出功率为１００ｍＷ，每次光剂量６０～１００Ｊ／ｃｍ２，照射时间８～１５ｍｉｎ。结果经１次（１例）和４次（４例）治疗后，患者皮损完全消退，恢复正常皮纹。随访６～１６个月，未见复发。结论ＡＬＡ－ＰＤＴ治疗Ｂｏｗｅｎ病简单、有效、耐受性好，为大面积Ｂｏｗｅｎ病的治疗提供了新思路更多还原

【Abstract】 Objective The treatment of Bowen’s disease is not always satisfactory with various methods such as surgery, laser, electrocoagulation, cryotherapy or radiotherapy. The objective of this study was to describe the satisfactory results of treatment for the disease using 5-aminolevulinic acid (ALA)-photodynamic therapy (PDT). Methods Five patients representing patches from 3.2 cm×3.0 cm to 4.5 cm× 3.0 cm in size on the skin of abdomen or thigh. The diagnosis of Bowen’s disease was confirmed by histopathological examination of biopsy. The ALA used was purchased from Sigma Chemical Co. and a 20% ALA cream was prepared freshly. It was applied topically under occlusive dressing for 3 h followed by irradiation. Light at 632.8 nm was obtained from a specially constructed He Ne laser and its output was set at 100 mW. Incident light doses of 60-100 J/cm 2 were applied, irradiating for 8-15 min. Results One patient was cured by one treatment and the other 4 cases by 4 times of treatment each, with an interval of 10-14 days. All lesions disappeared and the skin returned to normal appearance. No scar formation and no recurrence were observed by a follow up for 6-16 months. The cosmetic results were excellent. Conclusions ALA-PDT is a simple, effective and well tolerated treatment for Bowen’s disease. The good results obtained by this study warrent further study in patients with large lesions. More work is necessary to establish optimal ALA-PDT treatment schemes.更多还原