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二甲双胍对高血压病患者高胰岛素血症的治疗观察

Effect of Metformin on Hyperinsulinemia in Essential Hypertension Patients

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【作者】 张守荣高冠起刘键顾依群刘良福王月丽

【Author】 ZHANG Shourong1,GAO Guanqi2 LIU Jian1,GU Yiqun3,LIU Liangfu1,WANG Yueli2 \= (1.Department of Medicine,2.Department of endocrine,3.Department of pathology,Linyi City Hospital,Shandong province 276003)

【机构】 山东省临沂市人民医院

【摘要】 目的观察二甲双胍对高血压病患者血胰岛素水平的影响。方法23例高血压病患者,在降压治疗的基础上,加服二甲双胍。在年龄、性别、体重指数相匹配的18例高血压病,单纯应用同样降压药物。分析两组治疗前后血胰岛素的变化,并与正常人38例对照。结果二甲双胍组较单纯降压组空腹及餐后2小时血胰岛素分别明显下降(P<0.05,P<0.02)。结论二甲双胍较好地缓解高血压病的高胰岛素血症,并可能改善胰岛素抵抗及由此所致的代谢紊乱。

【Abstract】 Objective \ To observe the effect of metformin on hyperinsulinemia of essential hypertension(EH) patients.\ Z]Methods \ Twenty three EH patients treated by antithypertensive agents and methformin were compared with a group of 18 EH patients by antihypertensive agents alone. Two groups were matched in the respect of age,sex distribution and bodymass index. The changes of blood insulin before and after treatment in two group were studied.\ Results \ After treatment,fast and 2 hour postcarbohydrate load blood insulin in the metformin group all decreased significantly than that of antihypertensive group(P<0.05,P<002 respctively).\ Conclusion \ Metformin may lower EH hyperinsulinemia and improve EH insulin resistance.

  • 【文献出处】 高血压杂志 ,CHINESE JOURNAL OF HYPERTENSION , 编辑部邮箱 ,1999年02期
  • 【分类号】R544.1
  • 【被引频次】5
  • 【下载频次】69
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