【摘要】 目的为探讨老年高血压患者的血浆肾素活性（ＰＲＡ）、血管紧张素Ⅱ（ＡｎｇⅡ）水平与动态血压各参数值的关系。方法对５７例老年高血压患者及２６例健康老人在平衡饮食后行ＰＲＡ、ＡｎｇⅡ水平检查及２４小时动态血压监测。结果高血压组动态血压各参数值均显著高于对照组；与肾素正常者相比，高血压组中肾素增高者（ＰＲＡ＞８００ｎｇ／Ｌｈ）夜间平均收缩压、夜间平均舒张压及血压负荷值显著增高（Ｐ＜０．０１），２４小时平均收缩压亦明显增高（Ｐ＜０．０５），其夜间非构型发生率高。结论高肾素型老年高血压患者的２４小时血压节律消失，血压负荷值尤其是夜间血压负荷明显升高，易引起各靶器官的功能损害应当引起重视更多还原

【Abstract】 Aim\ To investigate the relationship between plasma renin activity(PRA),angiotensin Ⅱ(AngⅡ) and 24 hour ambulertory blood pressure mornitoring(ABMP) in elderly essential hypertensive patients.\ Methods\ After standard diet for 7 days,plasma PRA and AngⅡ were determined by radioimmunoassay. The hypertensive group was divided into two groups: (1)Group A PRA>800 ng·L -1 ·h -1 ;(2)Group B PRA<800 ng·L -1 ·h -1 .ABPM were carried out on all patients. \ Results\ Night SBP,night DBP and 24 hour BP load in group A were signifcantly higher than those of group B ( P< 0.01). The incidence of non dipper was higher in group A.\ Conclusion\ The high PRA type elderly hypertensive patients had prominent changement of BP dipper and BP load,this may be a risk factor for target organs damage.更多还原