【摘要】 探讨大鼠局灶脑缺血再灌注后神经节苷脂（ＧＭ１）的保护作用及其对碱性纤维母细胞生长因子的特异性受体（ＦＧＦＲ１）表达的影响。方法采用栓线法制备大脑中动脉缺血再灌注模型。通过腹腔注射给予ＧＭ１利用免疫组化方法检测ＦＧＦＲ１表达情况，并对病理学改变进行观察研究。结果与对照组相比，缺血再灌组ＦＧＦＲ１表达明显增多（Ｐ＜０．０１），而ＧＭ１用药组与缺血再灌组相比，ＦＧＦＲ１表达也明显增多（Ｐ＜０．０１）。光镜及电镜观察发现，单纯缺血再灌组梗塞区病理变化明显重于ＧＭ１用药组。结论脑缺血后ＧＭ１具有明确的保护作用，可减轻脑组织的损伤程度，并能使ＦＧＦＲ１表达上调。ＧＭ１可能通过影响ＦＧＦＲ１表达水平而发挥其作用。更多还原

【Abstract】 Objective To study the protective function of GM1 after cerebral ischcmic reperfusionand effect on the expression of FGFR1. Methods We made the local cerebral ischemic reperfusion model with thread embolism of middle cerebral artery. Immunostaining was used to study the expression ofFGFR1. Results The expression of FGFR1 in ischemic reperfusion group was significantly increased ascompared with control group. Furthermore,FGFR, expression of GM, group was significantly increasedas compared with ischemic reperfusion group. The pathological changes was also lighter than that of ischemic group. Conclusion GM1 has significantly cerebral protective effect and can induce upregulationof FGFR1 expression.更多还原