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罗汉果甜苷的生物活性研究

Studies on the Pharmacological Profile of Mogrosides

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【作者】 王霆黄志江蒋毅珉周曙苏玲姜世英刘国卿

【Author】 Wang Ting;Huang Zhijiang;Jiang Yimin, et al. (Department of Pharmacology, China Pharmaceutical University, Nanjing 210009)

【机构】 中国药科大学药理教研室!南京210009广西师范大学生物系

【摘要】 报道了罗汉果 Siraitia grosvenorii(Swingle) C. Jeffery ex Lu et Z. Y. Zhang提取物罗汉果甜苷(mogrosides,Mog)的祛痰、镇咳、平喘等药理作用。结果表明:Mog能增加小鼠气管酚红的分泌量,抑制氨水诱发的小鼠咳嗽,促进青蛙食道粘液移动,但并不影响枸橼酸诱发的豚鼠哮喘。提示Mog有化痰镇咳作用,是罗汉果的有效活性成分。

【Abstract】 The expectorant, antitussive and anti-asthmatic effects of mogrosides (Mog), extracted from traditional Chinese medicine Luohanguo [Siraitia grosvenorii (Swingle) C. Jeffery ex Lu et Z. Y. Zhang], was studied. Results of the study showed that Mog increased the secretion of PSP from mice bronchi, prompted the ciliary movement of frog esophagus and relieved cough caused by the irritation of ammonia water in mice. but did not alleviate the asthma induced by citric acid in mice. These data verified the truth of thousands years of Chinese medical practice in the use of the herb, and proved that MOG is the active composition of Luohanguo.

【关键词】 罗汉果甜苷祛痰镇咳
【Key words】 mogrosides expectorant antitussive
【基金】 中国药科大学科研基金
  • 【文献出处】 中草药 ,CHINESE TRADITIONAL AND HERBAL DRUGS , 编辑部邮箱 ,1999年12期
  • 【分类号】R284
  • 【被引频次】84
  • 【下载频次】548
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