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瘿消颗粒剂的药效学研究

Studies on the Pharmacodynamics of Ying Xiao Granule

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【作者】 张才丽王宏镛张京玲李冬生孙贵连

【Author】 Zhang Caili, Wang Hongyong, Zhang Jingling, et al. (Department of Pharmacology, Tianjin University of Medical Sciences, Tianjin 300070)

【机构】 天津医科大学药理学教研室!300070

【摘要】 正常小鼠po瘿消颗粒剂 20 d后,使小鼠机体耗氧量明显低于正常对照组,效果与他巴唑相同。瘿消颗粒剂对实验性甲状腺机能亢进家兔的体重、体温、心率、心电图、血清T、T值等各项指标均有明显改善,并使甲状腺的功能和形态基本恢复正常。它还可使正常大鼠血清T值下降,其作用与他巴唑相似,说明该方剂有明显的抗甲状腺机能亢进作用。

【Abstract】 Oral administration of Ying Xiao granule (YXG) to normal mice for 20 days, resulted in a pronounced decrease of oxygen consumption as compared with that of the normal controls. The effect was almost same as Thiamazole. YXG prominently improved the body weight, body temperature, heart rate, EKG, and serum T3, T4 values of experimental hyperthyroidism rabbits, and basically recovered their thyroid functions and morphology. This preparation also decreased serum T4 of euthyroid rats with a similar effect as Thiamazole. These restults showed that YXG has strong antithyroid effects.

  • 【文献出处】 中草药 ,CHINESE TRADITIONAL AND HERBAL DRUGS , 编辑部邮箱 ,1999年03期
  • 【分类号】R285
  • 【被引频次】1
  • 【下载频次】41
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