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1-(Z)-[2-(三芳基锡基)乙烯基]环戊醇及其衍生物的合成及生物活性
Syntheses and Biological Activities of 1(Z) (Triarylstannyl)vinyl] Cyclopentanols and Their Derivatives
【摘要】 合成了14种新的(Z)[2(三芳基锡基)乙烯基]环戊醇类有机锡化合物,通过元素分析、IR、1HNMR对所合成的化合物进行了表征,结果表明(Z)[2(三芳基锡基)乙烯基]环戊醇类有机锡化合物中乙烯式双键为顺式构型,分子内羟基与锡原子发生配位,形成五元螯合环.生物活性测定结果表明,二卤化物在抗癌,免疫及受体作用等方面具有优良的活性.
【Abstract】 Fourteen 1(Z cyclopentanols were prepared by the reaction of triaryltin hydrids with 1ethynylcyclopentanol. The reaction of compounds 1 and 2 with ICI, Br2, and I2 gave six organotin halides, respectively. The compounds were characterized by elemental analysis, IR, 1H NMR and some of them showed antitumor and immune activities.
【关键词】 (Z)-[(三芳基锡基)乙烯基]环戊醇;
合成;
生物活性;
【Key words】 triarylstannylvinyl cyclopentanol; synthesis; biological activity;
【Key words】 triarylstannylvinyl cyclopentanol; synthesis; biological activity;
【基金】 国家自然科学基金
- 【文献出处】 应用化学 ,CHINESE JOURNAL OF APPLIED CHEMISTRY , 编辑部邮箱 ,1999年02期
- 【分类号】TQ265.2
- 【被引频次】20
- 【下载频次】69