【摘要】 目的 实验研究急性心肌梗塞早期(6小时)的影像学变化并评价体外反搏对其的影响。方法 对14头杂种幼猪用闭胸式改良中孔合金珠法造成急性心肌梗塞模型,6小时及7小时分别行DSA血管造影及超声心动图检查,其中7头在6小时时行体外反搏治疗1小时,其余不作任何处理观察1小时,7小时时处死,取病理。结果 1:实验组左心功能(收缩及舒张功能)较对照组明显改善(P<0.01)。2;实验组梗塞变性范围较对照组明显缩小(P<0.01)。3 病理证实龙胆紫染色的心肌区即是心肌梗塞区,表现为典型的缺氧损伤。4:经受损的冠状动脉行DSA造影所显示的心肌染色区的体积与龙胆紫染色的心肌体积相符合,两者无显著性差异(P>0.05)。5:对照组显示典型的缺氧损伤,实验组则明显减轻。结论 DSA造影可以定量显示急性心肌梗塞的范围,心动超声图可测量左心功能的变化,是评价体外反搏治疗急性心肌梗塞的客观依据。更多还原

【Abstract】 Purpose To study experimentally the imaging changes of acute myocardial infarction at early stage(6 hours),and estimated effect of external counter pulsation(ECP). Methods 14 hybrid infant pigs were used in the test,the improved alloyBread method was performed to induce acute myocardial infarction, at the 6h and the 7h,madeDSA and Doppler’s echocardiography examination, 7 pigs made ECP treatmeat. All pigs dissected heart in living at the 7h. Results 1 The left ventricular function (diastohc and systolic function) of the test group improved considerably (P<0.01) 2 The infarction area of the test group was largely reduced in contrast with that of control group (P<0.01). 3 The pathological examination confined the tinctorial myocardium with gentian means region of myocardial infarction. It displayed the typical anoxic change. 4 The volume of tinctorial myocardium in DSA was similar to the volume of tinctorial myocardium with gentian(P>0. 05). 5 The infarction area of control group displayed the typical anoxic change while that of the test group was alleviated considerably. Conclusion DSA can be reliable on quantitating the AMI area;Doppler’s echocardiography can measure changes of the left ventricular function There is a proof in evaluation of ECP treatment to AMI.更多还原