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叶下珠中新多酚化合物的分离与鉴定

ISOLATION AND IDENTIFICATION OF A NOVEL POLYPHENOLIC COMPOUND FROM PHYLLANTHUS URINARIA

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【作者】 陈玉武任丽娟李克明张永文

【Author】 Chen Yuwu (Chen YW), Ren Lijuan (Ren LJ), Li Keming (Li KM) and Zhang Yongwen (Zhang YW) (China Japan Friendship Institute of Clinical Medical Sciences, Beijing 100029)

【机构】 中日友好医院临床医学研究所

【摘要】 目的:研究植物药叶下珠(PhylanthusurinariaL.)的化学成分。方法:用各种色谱技术进行分离纯化,经MS,1H,13CNMR和HMBC光谱分析鉴定其结构。结果:分得4个多酚类化合物,其结构分别鉴定为1O没食子酰基3,6六羟基联苯二甲酰基2,4去羟甲基诃子酰基吡喃葡糖(I),焦酚(pyrogalol,I),咖啡酸(cafeicacid,II)和(brevifolincarboxylicacid,IV)。结论:化合物I为一新的鞣花单宁(命名为phylanthusinU),I,II,IV为首次从该植物中分得。

【Abstract】 AIM: To study the chemical constituents the medicinal plant Phyllanthus urinaria L. METHODS: The constituents were separated and purified by using various chromatographies. The structural elucidation of the compounds were based on the analysis of their MS, 1H & 13 CNMR and HMBC spectra. RESULTS: Four polyphenolic compounds were obtained from P.urinaria and their structures were identified as: 1 O galloyl 3,6 O HHDP 2,4 O dehydroxymethyl chebuloyl β D glucopyranose (I), pyrogallol (II), caffeic acid (III) and brevifolincarboxylic acid (IV). CONCLUSION: Compound I was found to be a novel ellagitannin, named phyllanthusiin U, and II~IV were isolated from this plant for the first time.

  • 【文献出处】 药学学报 ,ACTA PHARMACEUTICA SINICA , 编辑部邮箱 ,1999年07期
  • 【分类号】R284.1
  • 【被引频次】26
  • 【下载频次】274
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