【摘要】 山茱萸为山茱萸科植物（ＣｏｒｎｕｓｏｆｆｉｃｉｎａｌｉｓＳｉｅｂ．ｅｔＺｕｃｃ．）的干燥成熟果肉，为常用中药，有补肝肾、涩精气、强壮、收敛等功效［１］。山茱萸总苷有明显的免疫抑制活性［２，３］，能抑制小鼠淋巴细胞转化，抑制ＬＡＫ细胞生成和白细胞介素?..更多还原

【Abstract】 AIM: To investigate the chemical constituents of the plant drug Cornus officinalis Sieb et Zucc. which is widely used in Chinese traditional medicine, having actions of invigorating the liver and kidney, strengthening the body, and of an astringent, etc. METHODS: A sedoheptulose gallate was isolated from the water extracts of fruits of C.officinalis using various chromatographies. The structure determination was based on spectral (UV, IR, 1H & 13 CNMR and MS) and chemical evidence. RESULTS: Its structure was characterized to be 7 O galloyl D sedoheptulose (I). The proportion of its three major conformation forms of β F , α F and α P in aqueous solution was estimated to be 57∶24∶19 according to their C 1 peak heights in the 13 CNMR spectrum. CONCLUSION: I was found in natural world for the first time and its β D heptufuranosyl form was the predominant existing tautomer in its equilibrated aqueous solution according to NMR determination.更多还原