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丝瓜叶成分对脑缺血大鼠学习记忆障碍及皮层体感诱发电位的影响

EFFECTS OF CONSTITUENTS L 6a and L 10 FROM LEAVES OF LUFFA CYLINDRICA ROEM ON DISFUNCTION OF LEARNING MEMORY AND SEP OF CEREBRAL ISCHMEIA RATS

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【作者】 齐尚斌周永禄李利民熊鹰隋建峰阮怀珍

【Author】 Qi Shangbin(Qi SB), Zhou Yonglu(Zhou YL), Li Limin(Li LM), Xiong Ying(Xiong Y) 1, Sui Jianfeng(Sui JF) 1 and Ruan Huaizhen(Ruan HZ) 1 (Sichuan Institute of Chinese Materia Medica, Chengdu 610041; 1The Third Military Medical University, C

【机构】 四川省中药研究所药理研究室!成都610041第三军医大学生理教研室!重庆400038

【摘要】 目的:研究丝瓜叶成分L6a 和L10 对脑缺血大鼠学习记忆障碍及皮层体感诱发电位(SEP) 的影响。方法:用脑缺血大鼠模型,侧脑室注射(icv)给药,以穿梭箱主动回避反应(AAR) 测定学习记忆行为;用SYD4228 型生理实验系统测定皮层体感诱发电位。结果:L6a 0-5 mg·kg- 1 显著促进脑缺血大鼠AAR的获得;0-25 mg·kg- 1 时,无明显影响;L6a 0-5 及0-25 mg·kg-1 均显著延缓AAR的消退;脑缺血后,L6a(0-5 mg·kg- 1) 也减缓SEP波幅下降及其潜伏期延长;脑缺血再通后,L6a 和L10(0-5 mg·kg- 1)均加大SEP振幅增高,缩短其潜伏期。结论:L6a 有显著促进脑障碍大鼠脑功能恢复的作用

【Abstract】 AIM: To study the effects of the constituents L 6a and L 10 from leaves of Luffa cylindrica Roem on learning memory disfunction and seduce electric potential (SEP) in cerebral ischemia rats. METHODS: The learning memory behavior was determined by active avoidance response (AAR) in shuttle box and the seduce electric potential (SEP) in cortical body sensation region was measured by SYD 4228 physiological experiment system in model of cerebral ischemia rat after injecting experimental drugs in cerebral ventricle (icv). RESULTS: Treatment with L 6a at dosage of 0 5 mg·kg -1 obviously promoted acquirement of AAR in cerebral ischemia rats ( P <0 05) and at doses of 0 5 and 0 25 mg·kg -1 obviously postponed the fading away of AAR ( P <0 05). Treatment with L 6a (0 5 mg·kg -1 ) was shown to relief the descent of SEP wave amplitude and the prolongation of SEP latent period after cerebral ischemia ( P <0 05). When blood was poured into brain again, both L 6a and L 10 were shown to markedly amplify SEP wave amplitude ( P <0 05) and shorten latent period of SEP. CONCLUSION: L 6a was found to obviously promote recovery of cerebral disfunction in rats.

【基金】 国家自然科学基金
  • 【文献出处】 药学学报 ,ACTA PHARMACEUTICA SINICA , 编辑部邮箱 ,1999年10期
  • 【分类号】R-332
  • 【被引频次】2
  • 【下载频次】91
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