【摘要】 目的：研究丝瓜叶成分Ｌ６ａ 和Ｌ１０ 对脑缺血大鼠学习记忆障碍及皮层体感诱发电位（ＳＥＰ） 的影响。方法：用脑缺血大鼠模型，侧脑室注射（ｉｃｖ）给药，以穿梭箱主动回避反应（ＡＡＲ） 测定学习记忆行为；用ＳＹＤ４２２８ 型生理实验系统测定皮层体感诱发电位。结果：Ｌ６ａ ０－５ ｍｇ·ｋｇ－ １ 显著促进脑缺血大鼠ＡＡＲ的获得；０－２５ ｍｇ·ｋｇ－ １ 时，无明显影响；Ｌ６ａ ０－５ 及０－２５ ｍｇ·ｋｇ－１ 均显著延缓ＡＡＲ的消退；脑缺血后，Ｌ６ａ（０－５ ｍｇ·ｋｇ－ １） 也减缓ＳＥＰ波幅下降及其潜伏期延长；脑缺血再通后，Ｌ６ａ 和Ｌ１０（０－５ ｍｇ·ｋｇ－ １）均加大ＳＥＰ振幅增高，缩短其潜伏期。结论：Ｌ６ａ 有显著促进脑障碍大鼠脑功能恢复的作用更多还原

【Abstract】 AIM: To study the effects of the constituents L 6a and L 10 from leaves of Luffa cylindrica Roem on learning memory disfunction and seduce electric potential (SEP) in cerebral ischemia rats. METHODS: The learning memory behavior was determined by active avoidance response (AAR) in shuttle box and the seduce electric potential (SEP) in cortical body sensation region was measured by SYD 4228 physiological experiment system in model of cerebral ischemia rat after injecting experimental drugs in cerebral ventricle (icv). RESULTS: Treatment with L 6a at dosage of 0 5 mg·kg -1 obviously promoted acquirement of AAR in cerebral ischemia rats ( P <0 05) and at doses of 0 5 and 0 25 mg·kg -1 obviously postponed the fading away of AAR ( P <0 05). Treatment with L 6a (0 5 mg·kg -1 ) was shown to relief the descent of SEP wave amplitude and the prolongation of SEP latent period after cerebral ischemia ( P <0 05). When blood was poured into brain again, both L 6a and L 10 were shown to markedly amplify SEP wave amplitude ( P <0 05) and shorten latent period of SEP. CONCLUSION: L 6a was found to obviously promote recovery of cerebral disfunction in rats.更多还原