The economical burden has been researched on the direct beneficiary in schistosomiasis control in lake area of Songzi city. The result showed that the coefficient of average burden of per beneficiary could be reached 1 %~1. 5% of the total expenses for the control with the goal of being controlled the diseases by the approach of Expended Chemotherapy for Mass and Cattle Plus Focus Mollusciciding.KeyWords: Schistosomiasis prevention and treatment; Direct Beneficiary; Coefficientof Average Burden