【摘要】 目的:研究肾综合征出血热疫苗效果免疫(感染)增强和免疫策略。方法:在疫苗试区设立对照组和接种组,观察期为1995年8月至1998年12月,全程接种3针,1年后加强1针。结果:全程接种了10178人,对照人群全程观察16159人,当年发病减少数为33例,4年平均保护率达93.89％。人群接种后局部和全身反应较明显。全程接种后2周荧光(IFA)抗体和中和抗体阳转率分别为100％和44.44％,一年后分别下降到28.57％和14.80％;加强后2周IFA抗体和中和抗体阳转率分别反弹至83.33％和55.56％,其抗体几何平均滴度(GMT)也随之下降和回升。结论:疫苗是安全有效的,有较好的血清学效果和流行病学效果,有免疫增强反应,但未发现感染增强反应。此外,加强免疫很有必要。更多还原

【Abstract】 Xikou town was chosen as observed sopt where high incidence of HFRS was noticed in Zhejiang province. Vaccinated group and control group were observed in the spot from August,1995 to December, 1998. People in vaccinated group received full(3)dose of vaccine and I booster dose after I year. Results 10178 people completed their vaccination of full close and the rate is 97. 30% (10178/10460). 16159 non-vaccinated people living in the same area as the vaccinees were used as the control group. 33 cases of HFRS was reduced to occur in the year after vaccination and the mean protection rate in 4 years was 93. 89%. The incidence of side effects of the vaccine was very hihg,the side effects mainly were local inching, sweeling, induration and some general sympotoms. 2 weeks after the injection of the full does, the seroconversion rate by immunofluorescent antibody test (Ig G) and neutralization test were 100% and 44. 44%. After I year,they were 28. 57% and 14. 80% respectively. They became 83.33% and 55. 56% ,53. 13% and 31. 25% ,22. 58% and 26.00% respectively when 2 weeks,1 year,3/2 year and 2 years after booster vaccination. The GMTs of them were 72. 12 and 4. 62,8. 14 and 2. 77,13. 44 and 4. 87,18. 02 and 3. 18,4. 32 and 2. 05, 2. 46 and 1. 96.更多还原