【摘要】 目的探讨环孢霉素A（CsA）联合地塞米松局部滴眼预防高危穿透角膜移植（PKP）免疫排斥反应的效果。方法将77眼高危PKP分为CsA组（37眼）：2％CsA蓖麻油溶液联合地塞米松满眼；对照组（40眼）单独使用地塞米松滴眼。采用生存曲线进行比较。结果术后2年，两组植片存活率分别为78％和60％，差异有显著性（P＜0．05）。结论2％CsA蓖麻油溶液联合地塞米松溶液局部滴眼是预防高危PKP免疫排斥反应的一种较好方法。更多还原

【Abstract】 Objective To evaluate the effect of topical cyclosporin A(CsA) in preventing rejection after high-risk penetrating allograft keratoplasty (PKP). Methods 77 eyes of 77 patients with high-risk PKP(ie: bullous keratopathy, regrafting or neovascularization) were randomly divided into two groups: (1)37 eyes were treated by CsA 2% castor oil and dexam ethasone, (2)40 eyes by dexamethasone only as control. The rejection free survival rate was calculated by Kpalan-Meier’s life table analysis.Results The survival rate at two yeare was 89% in CsA groups and 60% in control. The difference was significant(P<0.05). Conclusion Topical CsA in castor oil and dexamethasone were effective in prevent ing allograft rejection after high-risk PKP.更多还原