【摘要】 目的　探讨纤维连接蛋白 (FN)的表达与胃癌分化、浸润和转移的关系。方法　采用免疫组化S—P法检测 5 1例胃癌组织中FN的表达。结果　FN分布于上皮、基底膜及间质中。胃癌组织中细胞FN、基膜FN及间质FN的阳性率分别为 4 7 1%、 3 7 3 %、 74 5 %。癌细胞FN和基膜FN减少的程度与胃癌的分化程度及淋巴结转移有密切关系 ,而间质FN与胃癌的生物学特性无关。结论　细胞FN和基膜FN减少或消失是胃癌的特征之一 ,可能也是胃癌浸润转移的标志之一。更多还原

【Abstract】 To explore the relationship between the expressions of fibronectin(FN)in the tissues of gastric carcinoma and its different differentiation,infiltration,and lymphnode metastasis.Methods The expressions of FN were detected by S-P method.Results In the normal gastric tissues,FN were localized in epitheleal cells,basement membranes(BM)and interstitial tissues.In the gastric carcinoma,the positive rates of expressions of cell FN,BM FN and interstitial FN were 47 1%,37 3%,and 74 5% respectively.The decrease of cancer cell FN and BM FN were related to its degree of differentiation and lymphnode metastasis.The interstitial FN had no relation to the biological behavior of this tumor.Conclusion The decrease or absence of cell FN and BM FN may be one of the characteristics of gastric carcinoma,and also may be connected to the mechanism of its infiltration and metastasis.更多还原