【摘要】 目的观察香茶菜属植物香茶菜的新有效成分TAA₁对甲型溶血链球菌所致兔细菌性心内膜炎的治疗作用。方法自兔右颈总动脉插入聚乙烯管 ,其前端至左心室腔内 ,24h后静脉注射109CFU的甲型溶血链球菌 ,建立兔实验性心内膜炎模型。感染24h后分为2组 :Ⅰ为对照组 ,给予NS0.4ml·kg-1;Ⅱ为TAA₁治疗组 ,给予TAA₁0.25mmol·kg-1。ip ,每天1次 ,共治疗7d。最后一次给药后24h取动脉血测菌落计数后 ,将动物处死。部分心脏作解剖学和组织病理学检测 ;部分心脏用于取主动脉瓣赘生物和壁性赘生物 ,称重后行菌落计数。结果对照组主动脉瓣赘生物和壁性赘生物的重量、赘生物菌落计数和血液菌落计数均高于治疗组 ;治疗组心内膜及心肌组织结构的损伤程度明显小于对照组。结论TAA₁对细菌性心内膜炎有较好的治疗作用。更多还原

【Abstract】 Aim The curative effect of TAA-1, a new component of Amethystoidin, on rabbit endocarditis induced by α-hemolytic streptococus was observed.Methods A sterile polythelene catheter was inserted through the right carotid artery of rabbits into the ventricle and 24 h after the operation, every rabbit was given 109CFU α-hemolytic streptococcus from ear vein. After 24 h, the animals were divided into two groups. Animals in the control group were treated with NS, 0.2 ml·kg-1 and in the treatment group with TAA-1, 0.25 mmol·kg-1 ,ip qd for 7d. All the animals were scarified, some tissues of the heart were used for examination of the histological changes and some for observation of the aortic and ventricale neoplasm. Results In the treatment group, the neoplasms were smaller.Both the count of organisms in blood and neoplasm and the injury degree of myocardium were much less than in the control group.Conclusion TAA-1 has curative effect to endocarditis induced by α-hemolytic streptococcus.更多还原