【摘要】 目的　研究细胞间粘附分子１（ＩＣＡＭ１） 在葡萄膜炎免疫反应中的作用。 方法　应用免疫组织化学染色检查２０ 只正常眼和５４ 例葡萄膜炎眼球摘除眼的脉络膜和视网膜组织中ＩＣＡＭ１ 的表达。 结果　正常眼的脉络膜和视网膜组织没有ＩＣＡＭ１ 的阳性染色，葡萄膜炎眼中有增高表达（ Ｐ＜ ０ ．０１） ，外源性和内源性葡萄膜炎眼组间ＩＣＡＭ１ 表达统计学上无显著差异（ Ｐ＞ ０ ．０５） 。 结论　葡萄膜炎发病过程中，ＩＣＡＭ１ 介导白细胞和炎症部位组织细胞的识别和粘附，导致眼部组织的免疫性损伤更多还原

【Abstract】 ObjectiveTo study the effects of intercellular adhesion molecule 1(ICAM 1) on the immunopathologic process in uveitis.MethodsImmunohistochemical techniques were applied to detect ICAM 1 in eyes from the 20 healthy eye bank control eyes and eyes from patients with uveitis.ResultsICAM 1 was deteсtable on the choroidal and retinal tissues in eyes with uveitis while all the normal eyes lacked expression of ICAM 1( P <0.01).There were no statistically significant differences between exogenous and endogenous uveitis( P >0.05).ConclusionICAM 1 may be responsible for cell recognition and binding in inflammatory tissues and play an important role in immunologic damage of choroidal and retinal tissues in uveitis.更多还原