【摘要】 目的　探讨 Ｓ１００ 蛋白和 Ｈ Ｍ Ｂ４５ 单克隆抗体在恶性黑素瘤诊断中的价值。方法　以痣细胞痣、乳腺癌、卵巢癌作为对照病例，对５８ 例恶性黑素瘤进行 Ｓ Ｐ 免疫组化染色。结果　５８ 例恶性黑素瘤中 Ｈ Ｍ Ｂ４５ 阳性５６ 例（９６６ ％ ） ，对照组有３ 例阳性； Ｓ１００ 蛋白染色有５５ 例阳性（９４８ ％ ） ，对照组中，痣细胞痣１００ ％ 阳性，乳腺癌、卵巢癌中偶见阳性病例。结论　 Ｓ１００ 蛋白和 Ｈ Ｍ Ｂ４５ 单克隆抗体对恶性黑素瘤的诊断敏感性均较高，但 Ｓ１００ 蛋白的特异性较 Ｈ Ｍ Ｂ４５ 差，两者联合应用有助于恶性黑素瘤的诊断。更多还原

【Abstract】 Objective To investigate the effects of S 100 protein and H M B45 monoclonal antibodies in thediagnosis of malignant melanomas . Methods With a group case control study on nevocellular nevi, breastcancers, ovary cancers , 58 cases of malignant melanomas were stained with S P method ofim munohistochemistry. Results Among 58 cases of malignant melanomas, 56 cases are H M B45 positive(96 6 % ) . There were only 3 positive cases in the controls .55 cases were S 100 protein positive (94 8 % ) . Inthe controls ,all nevocellular nevi were positive (100 % ) . In the cases of breast cancers and ovary cancers ,therewasfew positive . Conclusion S 100 protein and H M B45 are higher sensitive in the diagnosis of malignantmelanomas ,but the specificity of S 100 protein islowerthan that of H M B45 . The com bination of S 100 proteinand H M B45 helps to the diagnosis of malignant melano mas .更多还原