【摘要】 目的　探讨烹调油烟（ＣＯＦ） 致肺损伤及毒作用机理。方法　利用ＳＤ 大鼠动式吸入烹调油烟［（４３ ±４）ｍｇ／ｍ３］ 制备动物模型，分三个时相（２０ 、４０ 、６０ ｄ） 观察ＣＯＦ 对肺脏Ｓ９ 中ＳＯＤ 活性，ＭＤＡ 和微量元素Ｚｎ 、Ｃｕ 、Ｆｅ 含量及组织病理学变化。结果　ＣＯＦ可使肺组织ＭＤＡ 含量增多，ＳＯＤ 酶活性下降；Ｚｎ 、Ｃｕ、Ｆｅ 代谢紊乱，以吸入ＣＯＦ６０ 天改变最明显；肺组织出现不典型增生等癌前病变。结论　长期吸入ＣＯＦ引起肺脂质过氧化和微量元素紊乱可能与肺损伤及其癌前病变存在一定的联系。更多还原

【Abstract】 Objective To observe the lung lesion and mechanism in SD rats inhaled cooking oil fumes (COF). Methods After inhalation of COF [(43±4)mg/m 3, 30 min/d, 20,40,60 d], the concentration of malonyldialdehyde (MDA), the activity of superoxide dismutase (SOD) the changes of trace elements and histopathological changes of lung tissues in rats were observed. Results COF inhalation group appeared to have higher MDA content and lower SOD activities than that of the control group. Metabolic disorder of trace elements in rat lung tissue was found to be more significant in the 60 days ( P <0.01). COF might also induce adenic metaplasia and precancerous pathological changes. Conclusion Long term inhalation of COF might induce lipid peroxidation and metabolic disorder of trace elements in lung and it might relate to the lung injury and even its precancerous changes.更多还原