【摘要】 目的：观察联合用药治疗类风湿关节炎以提高青藤碱疗效，减少不良反应。方法：联合用药组３５ 例，其中男性１０ 例，女性２５ 例；年龄３９ ａ ±ｓ ８ａ ； 病程５ ａ ±４ ａ 。青藤碱组２８ 例，其中男性８ 例，女性２０ 例；年龄３８ ａ ±９ ａ ；病程５ ａ ±３ ａ 。２ 组均服青藤碱片８０ ｍ ｇ ， ｐｏ ，ｔｉｄ ×６ ｍｏ 。联合用药组另加用氯喹０ ．２５ ｇ ， ｐｏ ，ｑｎ ×２ ｍ ｏ 后减为０ ．１２５ ｇ ， 共服６ ｍｏ ； 雷公藤多苷（ 甙） 片２０ ｍｇ ， ｐｏ ， ｂｉｄ ×６ｍｏ 。结果：联合用药组和青藤碱组临床缓显率（ 缓解率加显效率） 分别为７４ ％ 和２５ ％ （ Ｐ＜ ０ ．０１） 。不良反应发生率分别为１１ ％ 和３２ ％ （ Ｐ＜ ０ ．０１） 。结论：联合治疗方案治疗类风湿关节炎，比单用青藤碱疗效高，不良反应少。更多还原

【Abstract】 AIM: To observe the efficacy of sinomenine in combination chloroquine and tripterygium wilfordii glycosides in treating rheumatoid arthritis. METHODS: Combined use group (M 10, F 25; age 39 a±s 8 a, course of disease 5 a±4 a) and sinomenine group (M 8, F 20; age 38 a±9 a, course of disease 5 a±3 a) were treated with sinomenine 80 mg, po, tid, for 6 mo. Combined use group was associated with chloroquine 0.25 g, po, qn, after 2 mo dose of chloroquine was reduced to 0.125 g, for 6 mo, tripterygium wilfordii glycosides 20 mg, po, bid, for 6 mo. RESULTS: In combined use group and sinomenine group, the remission and marked effective rates (remission plus marked effects rate were respectively 74% and 25%, P<0.01). The rates of adverse reaction were respectively 11% and 32%. The rates of adverse reaction of combined use group was decreased markedly. CONCLUSION: The combination drug therapy for treatment of rheumatoid arthritis in comparision with sinomenine singlely there is high efficacy and the lower rates of adverse reaction.更多还原