【摘要】 胰胆管注射牛磺胆酸制备大鼠急性坏死性胰腺炎模型，检测血液流变学指标、红细胞脆性，胰腺病理学检查。结果表明：急性坏死性胰腺炎大鼠全血粘度、血浆粘度、红细胞压积均显著升高；纤维蛋白原降低。红细胞脆性增加。在急性坏死性胰胰炎时，上述血液流变性改变，可能是胰腺进行性坏死，病情恶化的主要原因之一。更多还原

【Abstract】 Acute pancreatitis was induced in male Wistar rats by intrapancreatic duct injection of sodium taurocholate. Blood samples were obtained for hemorrheologic parameters and erythrocyte osmotic fragility test. Pancreatic tissue was obtained for pathologic study. Results: Blood viscosity, plasma viscosity, hematocrit, erythrocyte osmotic fragility were significantly elevated,erythrocyte sedimentation rate and fibrinogen decreased significantly in acute necrotizing pancreatitis rats compared with sham group. In rats with acute necrotizing pancreatitis,hemorrheology may be one of the important factors to the deteriorion of the disease.更多还原