【摘要】 本文考察了渗透促进剂Azone（AZ）、油酸（OA）、丙二醇（PG）等和离子导入法（Ag／AgCl或Pt电极，电流密度0.19mA／cm2，频率2000Hz，占／空比1：1）对褪黑激素（MT）皮肤渗透性的影响。MT能透过小鼠全皮，其稳态流量和渗透系数分别为1622×10-3μg／cm2．s和0.8888×10-6cm／s：100％AZ、5％AZ／PG和10％OA／PG处理皮肤后，MT的稳态流量分别是未处理组的7.61、7.03和2.98倍；MT作为非离子性药物，离子导入对其也有促渗作用，离子导入处理组的稳态流量是未处理组的2.19倍。结果表明渗透促进剂（AZ、OA）、离子导入法均能增加MT的经皮渗透。更多还原

【Abstract】 The permeation of melatonin (MT) through the full-thickness mouse skin treatedwith penetration enhancers such as laurocapram (AZ), oleic acid (OA) and propylene glycol (PG),and/or iontophoresis under the condition with Ag/AgCl or Pt electrode at a current density of 0. 19mA/cm2, frequency of 2000 Hz and on/off ratio of 1:1 was conducted. MT as an unionized lipophilicdrug could permeate through full-thickness mouse skin, whose steady-state flux and permeationcoefficient were 1.622×10-3 μg/cm2.s and 0.888×10-6 cm/s, respectively. Penetration enhancersincluding 100%AZ, 5%AZ/PG and 10%OA/PG increased the steady-state flux of MT to 7.61, 7.03and 2.98 times compared with that through untreated skin, respectively. The flux of MT wasenhanced by current application with Ag electrode with an enhancement factor of 2. 19. These resultsshowed that penetration enhancer AZ, OA and/or iontophoresis could enhance the skin permeation ofMT.更多还原