【摘要】 合成了3－甲基－7－氧－9－氟－10－烃氧基（或芳氧基）－2，3－二氢－7H－吡啶［1，2，3－de］苯并恶嗪－6－羧酸及其类似物，体外抗菌筛选证明10－烃氧基化合物（尤其是氟乙氧基化合物3d）的抗菌作用明显优于10－羟基化合物3a。体外抗肿瘤试验证明有的化合物对LAX和P388细胞株培养具有中等或较低的细胞毒。更多还原

【Abstract】 Some 3-methyl-7-oxo-9-fluoro-10-alkyloxy (or aryloxy)-2, 3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids and analogues were synthesized. The in vitroantibacterial tests showed that the effect of the 10-alkyloxy compounds (especially the fluoroethyloxycompound 3d) was much better than that of the 10-hydroxy compound 3a. The antitumor test showedthat some target compounds possessed moderate or low cytotoxicity against LAX and P388 in theculture.更多还原