【摘要】 目的：探讨气道高反应性在青少年哮喘发病过程中的作用。方法：利用遗传流行病学的方法，收集了支气管哮喘核心家系的资料，对家系中每一成员测定其气道反应性。结果：气道高反应性的亲属患哮喘的危险性明显增加，是没有气道高反应性亲属的8．10倍（P＜0．01）；其中气道高反应性的双亲和子女患哮喘的危险性分别增加7．10倍和4．59倍，有高度显著性意义；即使调整了遗传因素可能的混杂作用，气道高反应性子女患哮喘的危险性仍较无气道高反应性子女增加2．96倍（P＜0．01）。结论：气道高反应性不仅是支气管哮喘的重要特征，而且可能是支气管哮喘的重要危险因素。更多还原

【Abstract】 Objective:To explore the effect of hyperresponsiveness on children’asthma.Method:With the method of genetic epidemiology,230 nuclear families of asthma were investigated. Results:The family members with hyperresponsiveness were at 8.10 times higher risk for suffering from asthma than the those without hyperresponsivenes (OR= 7. 10,parents and OR = 4.59,children). Compared with children without hyperresponsiveness,children without hyperresponsiveness,still were high-risk asthma population after the confounded genetic factors were adjusted.Conclusion:Hyperresponsiveness is likely to be an important risk factor for asthma.更多还原