【摘要】 ［目的］探讨原发性输卵管癌的病因与发病过程，为该病的治疗方案制定及预后判断提供参考依据。［方法］通过免疫组织化学方法（标记用许氏 ＡＢＣ方法）对 ２４例原发性输卵管癌组织的 ｐ１６基因蛋白表达进行测定，并与 １１例正常输卵管上皮组织作对照。［结果］癌组织的ｐ１６阳性率为２９．１６％，明显低于正常组织阳性表达率（７２．７２％），两者差异有显著性。另外，ｐ１６的表达水平随组织学分级增高而增高。尤其６例有脉管内癌栓形成者中ｐ１６表达无一例外均为阴性。［结论］ｐ１６基因变异与原发性输卵管癌的发生和发展密切相关。ｐ１６基因蛋白的检测将有助于病情的判断和适当治疗方案的制定。更多还原

【Abstract】 Purpose] To evaluate the expression of p16 gene in primary fallopian tube carcinoma and its relationship to clinicopathological characteristics. [Methods] By immunohistochemistry technique. the expression of protein of p16 gene in samples from 24 patients with primary fallopian tube carcinoma were examined. The normal fallopian tube tissues from 11 cases were used as a control group. [Results] The positive expression rate of p16 gene protein in carcinoma cases were 29. 16%, lower than that in normal tissues (72.72% ) .There were significantly difference between them (P = 0.02) .The expression of p16 gene was strongly related to histoltogical grade (P = 0.019). Six cases with vessel carcinoma embolusion presented all negative expression of p16 gene. [Conclusion] It is shown that there is close relationship between the genesis, progression of primary fallopian tube carcinoma and mutation of p16 gene. p16 gene measurement will be helpful to evaluate prognosis and make effective therapeutic modality.更多还原